Just have a look at the latest from merlinofchaos.

panels1.jpg

This is the configuration interface behind the “add” tab of Panels Module. Panels is designed to let you put content in different areas on a page using different types of layouts. You can choose from the pre-configured layouts, or roll your own. All I can say is, if you are looking for a non-drupal look without writing themes by hand, go try it.